Biological Chemistry Group
Graduate School of Engineering Science
Osaka University

生体機能化学グループ｜岩井研究室

Our laboratory aims at elucidation of various phenomena of life,
from a viewpoint of chemistry, using knowledge and technology in the fields of organic chemistry,
physical chemistry, and molecular biology.
We are studying molecular recognition and reaction mechanisms of nucleic acids (DNA and RNA) and proteins,
and hope to apply the results of our basic research to development of functional molecules such as medicine.
Our educational policy is to give students opportunity to have a broad outlook on both chemistry and biology through interdisciplinary
researches.

ABOUT

当研究室では、有機合成化学・物理化学・分子生物学などの知識と技術を使って、化学の視点から生命現象の解明を目指しています。特に、核酸（DNAやRNA）とタンパク質の分子認識や反応機構を解明するための研究を行なっており、基礎研究の成果を創薬を目的とする機能性分子の創製などに応用したいと考えています。また、学際的な領域の研究を通して、化学と生物学の両方を理解し広い視野を持った人材の育成を行ないます。

Our laboratory aims at elucidation of various phenomena of life,
from a viewpoint of chemistry, using knowledge and technology in the fields of organic chemistry,
physical chemistry, and molecular biology.
We are studying molecular recognition and reaction mechanisms of nucleic acids (DNA and RNA) and proteins,
and hope to apply the results of our basic research to development of functional molecules such as medicine.
Our educational policy is to give students opportunity to have a broad outlook on both chemistry and biology through interdisciplinary researches.
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RESEARCH

遺伝子の本体であるDNAも有機分子ですので、種々の化学物質や紫外線、電離放射線などにより化学反応を受け、化学構造の変化（損傷）を生じます。 DNAの損傷は突然変異を引き起こし、細胞の死やがん化の原因となります。私たちは、紫外線により形成されるシクロブタンピリミジンダイマーを除去するバクテリオファージT4のエンドヌクレアーゼＶに関する共同研究に参加したことをきっかけに、損傷DNAの化学合成とそれを用いた分子生物学の研究を行ってきました。

Since DNA, the genetic material, is an organic molecule, it is subjected to chemical reactions with both endogenous and exogenous factors in cells. The products are called DNA lesions, and they induce genetic mutations, which result in carcinogenesis and cell death. We have been studying the chemical synthesis of lesion-containing DNA and its application to molecular biology.
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