Publications

Original Articles

2026

  1. Ito, K.; Manabe, Y.; Ohshima, S.; Maeki, M.; Tokeshi, M.; Inaba, H.; Matsuura, K.; Kabayama, K.; Kametani, Y.; Fukase, K.*
    Programmable Antigen-Specific Immunity via Self-Adjuvanting Nanovaccines Co-Delivering Immune Modulators.
    Angew. Chem. Int. Ed.2026, 65, e20474. DOI: 10.1002/anie.202520474
2025 and Earlier
  1. Tseng, H.-W.; Tseng, H.-K.; Ooi, K.-E.; You, C.-E.; Wang, H.-K.; Kuo, W.-H. Ni, C.-K.; Manabe, Y.; Lin, C.-C.*
    Controllable Enzymatic Synthesis of Natural Asymmetric Human Milk Oligosaccharides.
    JACS Au 2024, 4. 4496-4506. DOI: 10.1021/jacsau.4c00830.
  2. Kaneda-Nakashima K.*; Shirakami, Y.; Hisada, K.; Feng, S.; Kadonaga, Y.; Ooe, K.; Watabe, T.; Manabe, Y.; Shimoyama, A.; Murakami, M.; Toyoshima, A.; Haba, H.; Kanai, Y.; Fukase, K.
    Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-211.
    Int. J. Mol. Sci. 2024, 25. 12386. DOI: 10.3390/ijms252212386.
  3. Manabe, Y.; Tsutsui, Y.; Tanaka, Y.; Yokoyama, Y.; Ikinaga, Y.; Nishitani, T.; Yano, K.; Miyagawa, R.; Fukase, K.; Konishi, A.*; Yasuda, M.*
    Cage-Shaped Borate Catalysts Bearing Precisely Controlled Lewis Acidity and Its Application to Glycosylations.
    J. Org. Chem. 2024, 89. 15630-15635. DOI: 10.1021/acs.joc.4c01706. (Selected to supplementary journal cover)
  4. Manabe, Y.*; Takebe, T.; Kasahara, S.; Hizume, K.; Kabayama, K.; Kamada, Y.; Asakura, A.; Shinzaki, S.; Takamatsu, S.; Miyoshi, E.; García-García, A.; Vakhrushev, S. Y.; Hurtado-Guerrero, R.; Fukase, K.*
    Development of a FUT8 Inhibitor with Cellular Inhibitory Properties.
    Angew. Chem. Int. Ed. 2024, 63. e202414682. DOI: 10.1002/anie.202414682. (Selected to inside cover)
  5. Miura, A.; Manabe Y.*; Suzuki, K. G. N.; Shomura, H.; Okamura, S.; Shirakawa, A.; Yano, K.; Miyake, S.; Mayusumi, K.; Lin, C-C.; Morimoto, K.; Ishitobi, J.; Nakase, I.; Arai, K.; Kobayashi, S.; Ishikawa, S.; Kanoh, H.; Miyoshi, E.; Yamaji, T.; Kabayama, K.*; Fukase, K.*
    De Novo Glycan Display on Cell Surfaces Using HaloTag: Visualizing the Effect of the Galectin Lattice on the Lateral Diffusion and Extracellular Vesicle Loading of Glycosylated Membrane Proteins.
    J. Am, Chem. Soc. 2024, 146(32), 22193-22207. DOI: 10.1021/jacs.4c02040. (Selected to supplementary journal cover)
  6. Naini, A. A.; Mayanti, T.; Hilmayanti, E.; Huang, X.; Kabayama, K.; Shimoyama, A.; Manabe, Y.; Fukase, K.; Supratman, U.*
    Immunomodulatory of sesquiterpenoids and sesquiterpenoid dimers-based toll-like receptor 4 (TLR4) from Dysoxylum parasiticum stem bark.
    Sci. Rep. 2024, 14, 15597. DOI: 10.1038/s41598-024-65829-0.
  7. Seki, T.; Suzuki, R.; Ohshima, S.; Manabe, Y.; Onoue, S.; Hoshino, Y.; Yasuda, A.; Ito, R.; Kawada, H.; Ishimoto, H.; Shiina, T.; Kametani, Y.*
    Liposome-encapsulated progesterone efficiently suppresses B-lineage cell proliferation.
    Biochem. Biophys. Rep. 2024, 38, 101710. DOI: 10.1016/j.bbrep.2024.101710.
  8. Manabe,　Y.*; Gárate-Reyes, B.; Ito, K.; Hurtado-Guerrero, R.; Kabayama, K.; Fukase, K.*
    Synthesis and immunological evaluation of TLR1/2 ligand-conjugated RBDs as self-adjuvanting vaccine candidates against SARS-CoV-2.
    Chem. Commun. 2024, 60, 3946-3949. DOI: 10.1039/d4cc00462k
  9. Naini, A. A.; Mayanti, T.; Maharani, R.; Harneti, D.; Nurlelasari; Farabi, K.; Fajriah, S.; Hilmayanti, E.; Kabayama, K.; Shimoyama, A.; Manabe, Y.; Fukase, K.; Jungsuttiwong, S.; Prescott, T. A. K.; Supratman, U.*
    Paraxylines A-G: Highly oxygenated preurianin-type limonoids with immunomodulatory TLR4 and cytotoxic activities from the stem bark of Dysoxylum parasiticum.
    Phytochemistry 2024, 220, 114009. DOI: 10.1016/j.phytochem.2024.114009.
  10. Yano, K.; Yoshimoto, T.; Tsutsui, M.; Manabe, Y.*; Fukase, K.*
    Validation and Application of an Innovative Protective Group Concept: Enhancing Substrate Reactivity in Glycosylations by Disrupting Intermolecular Interactions.
    Synlett 2024, 35 DOI: 10.1055/a-2269-7680
  11. Carluccio, C. D.; Cerofolini, L.; Moreira, M.; Rosu, F.; Padilla-Cortés, L.; Gheorghita, G. R.; Xu, Z.; Santra, A.; Yu, H.; Yokoyama, S.; Gray, T. E.; St. Laurent, C. D.; Manabe, Y.; Chen, X.; Fukase, K.; Macauley, M. S.; Molinaro, A.; Li, T.; Bensing, B. A.; Marchetti, R.*; Gabelica, V.; Fragai, M.; Silipo, A.*
    Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBRUB10712) of Streptococcus gordonii.
    ACS Cent. Sci. 2024, 10, 447-459. DOI: 10.1021/acscentsci.3c01598
  12. Manabe, Y.*; Hizume, K.; Takakura, Y.; Takamatsu, S.; Miyoshi, E.; Kamada, Y.; Hurtado-Guerrero, R.; Fukase, K.*
    Systematic Strategy for the Development of Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors.
    Synlett 2024, 35 DOI: 10.1055/a-2221-9096
  13. Kametani, Y.*; Ito, Y.; Ohshima, S.; Manabe, Y.; Ohno Y.; Shimizu, Y.; Yamada, S.; Katano, N.; Kirigaya, D.; Ito, K.; Matsumoto, T.; Tsuda, B.; Kashiwagi, H.; Goto, Y.; Yasuda, A.; Maeki, M.; Tokeshi, M.; Seki, T.; Fukase, K.; Mikami, M.; Ando K.; Ishimoto, H..; Shiina, T.
    Construction of the Systemic Anticancer Immune Environment in Tumor-Bearing Humanized Mouse by Using Liposome-Encapsulated Anti-Programmed Death Ligand 1 Antibody-Conjugated Progesterone.
    Front. Immunol. 2023, 14, DOI: 10.3389/fimmu.2023.1173728
  14. Ito, K.; Furukawa, H.; Inaba, H.; Ohshima, S.; Kametani, Y.; Maeki, M.; Tokeshi, M.; Huang, X.; Kabayama, K.; Manabe, Y.*; Fukase, K.*; Matsuura, K.*
    Antigen/Adjuvant-displaying Enveloped Viral Replica as a Self-adjuvanting Anti-breast-cancer Vaccine Candidate.
    J. Am. Chem. Soc. 2023, 145(29), 15838-15847. DOI: 10.1021/jacs.3c02679 (Selected to supplementary journal cover).
  15. Iizuka, Y.; Manabe, Y.; Ooe, K.; Toyoshima, A.; Yin, X.; Haba, H.; Kabayama, K.*; Fukase, K.*
    Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy.
    Int. J. Mol. Sci. 2023, 24(11), 9593. DOI: 10.3390/ijms24119593
  16. Manabe, Y.*; Iizuka, Y.; Yamamoto, Y.; Ito, K.; Hatano, K.; Kabayama, K.*; Fukase, K.* Improvement of Antibody Activity by Controlling Its Dynamics Using the Glycan-Lectin Interaction.
    Angew. Chem. Int. Ed. 2023, 62(30), e202304779. DOI: 10.1002/anie.202304779 (Selected to inside back cover)
  17. Milawati, H.; Manabe, Y.*; Matsumoto, T.; Tsutsui, M.; Ueda, Y.; Miura, A.; Kabayama, K.; Fukase, K.
    Practical Antibody Recruiting by Metabolic Labeling with Caged Glycans.
    Angew. Chem. Int. Ed. 2023, 62(25), e202303750. DOI: 10.1002/anie.202303750 (Selected to the frontispiece at the beginning of the Communications section)
  18. Naini, A. A.; Mayanti, T.; Maharani, R.; Fajriah, S.; Kabayama, K.; Shimoyama, A.; Manabe, Y.; Fukase, K.; Jungsuttiwong, S. Supratman, U.*
    Dysoticans FH: three unprecedented dimeric cadinanes from Dysoxylum parasiticum (Osbeck) Kosterm. Stem bark.
    RSC. Adv. 2023, 13(14), 9370-9376. DOI: 10.1039/d3ra01085f.
  19. Hirao, K.; Speciale, I.; Notaro, A.; Manabe, Y.*; Teramoto, Y.; Sato T.; Atomi H.; Molinaro, A.; Ueda, Y.; Castro, C. D.*; Fukase, K.*
    Structural Determination and Chemical Synthesis of N-Glycan from the Hyperthermophilic Archaeon Thermococcus kodakarensis.
    Angew. Chem. Int. Ed. 2023, 62(13), e202218655. DOI: 10.1002/anie.202218655
  20. Sato, T.; Utashima, S.; Yoshii, Y.; Hirata, K.; Kanda, S.; Onoda, Y.; Jin J.; Xiao, S.; Minami, R.; Fukushima, H.; Noguchi, A.; Manabe, Y.; Fukase, K.; Atomi, H.*
    A non-carboxylating pentose bisphosphate pathway in halophilic archaea.
    Commun. Biol. 2022, 5, 1290. DOI: 10.1038/s42003-022-04247-2
  21. Tsutsui, Y.; Tanaka, D.; Manabe, Y.; Ikinaga, Y.; Yano, K.; Fukase, K.*; Konishi, A.*; Yasuda, M.*
    Synthesis of Cage-Shaped Borates Bearing Pyrenylmethyl Groups: Efficient Lewis Acid Catalyst for Photoactivated Glycosylations Driven by Intramolecular Excimer Formation.
    Chem. Eur. J. 2022, 28, e202202284. DOI: 10.1002/chem.202202284
  22. Manabe, Y.*; Tsutsui, M.; Hirao, K.; Kobayashi, R.; Inaba, H.; Matsuura, K.; Yoshidome, D.; Kabayama, K.; Fukase, K.*
    Mechanistic Studies for the Rational Design of Multivalent Glycodendrimers.
    Chem. Eur. J. 2022, 28, e202201848. DOI: 10.1002/chem.202201848
  23. Chang, T-C.; Manabe, Y.*; Ito, K.; Yamamoto, R.; Kabayama, K.; Ohshima, S.; Kametani, Y.*; Fujimoto, Y.; Lin, C-C; Fukase, K.*
    Precise Immunological Evaluation Rationalizes the Design of a Self-adjuvanting Vaccine Composed of Glycan Antigen, TLR1/2 Ligand, and T-helper Cell Epitope.
    RSC Adv. 2022, 12, 18985-18993. DOI: 10.1039/D2RA03286D
  24. Manabe, Y.; Matsumoto, T.; Ikinaga, Y.; Tsutsui, Y.; Sasaya, S.; Kadonaga, Y.; Konishi, A.*; Yasuda, M.*; Uto, T.; Dai, C.; Yano, K.; Shimoyama, A.; Matsuda, A.; Fukase, K.*
    Revisiting Glycosylations Using Glycosyl Fluoride by BF3∙Et2O: Activation of Disarmed Glycosyl Fluorides with High Catalytic Turnover.
    Org. Lett. 2022, 24, 6-10. DOI: 10.1021/acs.orglett.1c03233
  25. Carluccio, C.; Forgione, R. E.; Bosso, A.; Yokoyama, S.; Manabe, Y.; Pizzo, E.; Molinaro, A.; Fukase, K.; Fragai, M.; Bensing, B. A.; Marchetti, R.*; Silipo A.*
    Molecular recognition of sialoglycans by streptococcal Siglec-like adhesins: toward the shape of specific inhibitors.
    RSC Chem. Biol. 2021, 2, 1618-1630. DOI: 10.1039/d1cb00173f
  26. Shirakawa, A.; Manabe, Y.*; Marchetti, R.; Yano, K.; Masui, S.; Silipo, A.; Molinaro, A.; Fukase, K.*
    Chemical Synthesis of Sialyl N-Glycans and Analysis of Their Recognition by Neuraminidase.
    Angew. Chem. Int. Ed. 2021, 60, 24686-24693. DOI: 10.1002/anie.202111035
  27. Kaneda-Nakashima, K.*; Zhang, Z.; Manabe, Y.; Shimoyama, A.; Kabayama, K.; Watabe, T.; Kanai, Y.; Ooe, K.; Toyoshima, A.; Shirakami, Y.; Yoshimura, T.; Fukuda, M.; Hatazawa, J.; Nakano, T.; Fukase, K.; Shinohara, A.
    α-Emitting cancer therapy using 211At‐AAMT targeting LAT1.
    Cancer Sci., 2021, 112(3), 1132-1140. DOI: 10.1111/cas.14761
  28. Carluccio, D. C., Forgione, R. E.; Montefiori, M.; Civera, M.; Sattin, S.; Smaldone, G.; Fukase, K.; Manabe, Y.; Crocker, P. R.; Molinaro, A.; Marchetti, R.*; Silipo, A.*
    Behavior of glycolylated sialoglycans in the binding pockets of murine and human CD22.
    iScience, 2021, 24(1), 101998. DOI: 10.1016/j.isci.2020.101998
  29. Tsutsui, M.; Manabe, Y.*; Kabayama, K.; Fukase, K.*
    Synthesis of ABO blood group antigens and functional glycan display on the cell surface.
    Arkivoc, 2021, iv, 168-185. DOI: 10.24820/ark.5550190.p011.362
  30. Farabi, K.; Manabe, Y.*.; Ichikawa, H.; Miyake, S.; Tsutsui, M.; Kabayama, K.; Yamaji, T.; Tanaka, K.; Hung, S.-C.; Fukase, K.*
    Concise and Reliable Syntheses of Glycodendrimers via Self-Activating Click Chemistry: A Robust Strategy for Mimicking Multivalent Glycan–Pathogen Interactions.
    J. Org. Chem. 2020, 85(24), 16014-16023. DOI: 10.1021/acs.joc.0c01547
  31. Hirao, K.; Ono, R.; Manabe, Y.*; Masui, S.; Atomi, H.; Fukase, K.*
    Total Syntheses of C60- and C100-Dolichols.
    J. Org. Chem. 2020, 85(17), 11549-11559. DOI: 10.1021/acs.joc.0c01327
  32. Forgione, R.E.; Di Carluccio, C.; Guzmán-Caldentey, J.; Gaglione, R.; Battista, F.; Chiodo, F.; Manabe, Y.; Arciello, A.; Del Vecchio, P.; Fukase, K.; Molinaro, A.; Martín-Santamaría, S.; Crocker, P.R.; Marchetti, R.*; Silipo, A.*
    Unveiling Molecular Recognition of Sialoglycans by Human Siglec-10.
    iScience 2020, 23(6), 101231. DOI: 10.1016/j.isci.2020.101231
  33. Aiga, T.; Manabe, Y.*; Ito, K.; Chang, T-C.; Kabayama, K.; Ohshima, S.; Kametani, Y.; Miura, A.; Furukawa, H.; Inaba, H.; Matsuura, K.; Fukase, K.*
    Immunological Evaluation of Co‐assembling a Lipidated Peptide Antigen and Lipophilic Adjuvants as Self‐adjuvanting Anti‐breast Cancer Vaccine Candidates.
    Angew. Chem. Int. Ed. 2020,　59(40), 17705-17711. DOI: 10.1002/anie.202007999
  34. Tsutsui, M.; Sianturi, J.; Masui, S.; Tokunaga, K.; Manabe, Y.*; Fukase, K.*
    Efficient synthesis of antigenic trisaccharides containing N-acetylglucosamine: protection of NHAc as NAc2.
    Eur. J. Org. Chem. 2020, 2020, 1802-1810. DOI: 10.1002/ejoc.201901809 (Selected as a cover)
  35. Forgione, R. E.; Carluccio, C. C.; Kubota, M.; Manabe, Y.; Fukase, K.; Molinaro, A.; Hashiguchi, T.; Marchetti, R.; Silipo, A.*
    Structural basis for Glycan-receptor binding by mumps virus hemagglutinin-neuraminidase.
    Sci. Rep. 2020, 10, 1589. DOI: 10.1038/s41598-020-58559-6
  36. Masuda, R.; Kawasaki, Y.; Igawa, K.; Manabe, Y.; Fujii, H.; Kato, N.; Tomooka, K.; Ohkanda, J.*
    Copper‐free Huisgen Cycloaddition for the 14‐3‐3‐Templated Synthesis of Fusicoccin‐Peptide Conjugates.
    Chem. Asian. J. 2020, 15, 742-747. DOI: 10.1002/asia.202000042
  37. Manabe, Y.; Marchetti, R.; Takakura, Y.; Nagasaki, M.; Nihei, W.; Takebe, T.; Tanaka, K.; Kabayama, K.; Chiodo, F.; Hanashima, S.; Kamada, Y.; Miyoshi, E.; Dulal, H. P.; Yamaguchi, Y.; Adachi, Y.; Ohno, N.; Tanaka, H.; Silipo, A.; Fukase, K.*; Molinaro, A.*
    The core fucose on an IgG antibody is an endogenous ligand of Dectin-1.
    Angew. Chem. Int. Ed. 2019, 58, 18697-18702. DOI: 10.1002/anie.201911875
  38. Feng, Q.; Manabe, Y.; Kabayama, K.*; Aiga, T.; Miyamoto, A.; Ohshima, S.; Kametani, Y.; Fukase, K.*
    Syntheses and functional studies of self-adjuvanting anti-HER2 cancer vaccines.
    Chem. Asian. J. 2019, 14, 4268-4273. DOI: 10.1002/asia.201901002
  39. Tanaka, D.; Kadonaga, Y.; Manabe, Y.; Fukase, K.*, Sasaya, S.; Maruyama, H.; Nishimura, S.; Yanagihara, M.; Konishi, A.*; Yasuda M.*
    Synthesis of Cage-Shaped Aluminum Aryloxides: Efficient Lewis Acid Catalyst for Stereoselective Glycosylation Driven by Flexible Shift of Four- to Five-Coordination.
    J. Am, Chem. Soc. 2019, 141, 17466-17471. DOI: 10.1021/jacs.9b08875 (Selected as a cover)
  40. Carluccio, C. D.; Crisman, E.; Manabe, Y.; Forgione, R. E.; Lacetera, A.; Amato, J.; Pagano B.; Randazzo, A.; Zampella, A.; Lanzetta, R.; Fukase, K.; Molinaro, A.; Crocker, P. R.; Martin-Santamaria, S.; Marchetti, R.; Silipo A.*
    Characterisation of the dynamic interactions between complex N-glycans and human CD22.
    ChemBioChem 2019, 21, 129-140. (Selected as a cover) DOI: 10.1002/cbic.201900295
  41. Sianturi, J.; Manabe, Y.; Li, H-S.; Chiu, L-T.; Chang, T-C.; Tokunaga, K.; Kabayama, K.; Tanemura, M.; Takamatsu, S.; Miyoshi, E.; Hung, S-C.; Fukase, K.*
    Development of α-Gal Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies.
    Angew. Chem. Int. Ed. 2019, 58, 4574-4578. DOI:10.1002/anie.201812914
  42. Masui, S.; Manabe, Y.; Hirao, K.; Shimoyama, A.; Fukuyama, T.; Ryu, I.; Fukase, K.*
    Kinetically controlled Fischer glycosidation under flow conditions: A new method for preparing furanosides.
    Synlett, 2019, 30, 397-400. DOI: 10.1055/s-0037-1611643
  43. Yeh, C.-J.; Ku, C.-C.; Lin, W.-C.; Fan, C.-Y.; Zulueta, M.M.L.; Manabe, Y.; Fukase, K.*; Li, Y.-K.; Hung, S.-C.*
    Single-Step Per-O-Sulfonation of Sugar Oligomers with Concomitant 1,6-Anhydro Bridge Formation for Binding Fibroblast Growth Factors,
    ChemBioChem 2019, 20, 237-240. DOI:10.1002/cbic.201800464
  44. Kabayama, K.*; Kaneda, K.; Shinohara, A.; Shirakami, Y.; Watabe, T.; Zhang, Z.; Toyoshima, A.; Yoshimura, T.; Manabe, Y.; Shimoyama, A.; Fukase, K.*
    Activities of the Consortium for Medicine, Chemistry, and Physics at Osaka University.
    J. Med. Radiat. Sci. 2019, 50, S1. DOI: 10.1016/j.jmir.2019.03.121
  45. Nakamoto, Y.; Pradipta, A.R.; Mukai, H.; Zouda, M.; Watanabe, Y.; Kurbangalieva, A.; Ahmadi, P.; Manabe, Y.; Fukase, K.; Tanaka, K.*
    Expanding the Applicability of the Metal Labeling of Biomolecules by the RIKEN Click Reaction: A Case Study with Gallium-68 Positron Emission Tomography,
    ChemBioChem, 2018, 19, 2055-2060. DOI:10.1002/cbic.201800464
  46. Handa-Narumi, M.; Yoshimura, T.; Konishi, H.; Fukata, Y.; Manabe, Y.; Tanaka, K.; Bao, G.-M.; Kiyama, H.; Fukase, K.; Ikenaka, K.*
    Branched sialylated N-glycans are accumulated in brain synaptosomes and interact with Siglec-H,
    Cell Struct. Funct. 2018, 43, 141-152. DOI: 10.1247/csf.18009
  47. Chang, T.-C.; Manabe, Y.; Fujimoto, Y.; Ohshima, S.; Kametani, Y.; Kabayama, K.; Nimura, Y.; Lin, C.-C.; Fukase, K.*
    Syntheses and Immunological Evaluation of Self-Adjuvanting Clustered N-Acetyl and N-Propionyl Sialyl-Tn Combined with A Thelper Cell Epitope as Antitumor Vaccine Candidates.
    Angew. Chem. Int. Ed. 2018, 57, 8219-8224. DOI: 10.1002/anie.201804437
  48. Manabe, Y.; Shomura, H.; Minamoto, N.; Nagasaki, M.; Takakura, Y.; Tanaka, K.; Silipo, A.; Molinaro, A.; Fukase K.*
    Convergent synthesis of a bisecting GlcNAc-containing N-glycan.
    Chem. Asian. J. 2018, 13, 1544-1551. DOI: 10.1002/asia.201800367
  49. Suzuki, T.*; Ishigaki, Y.; Sugawara, K.; Umezawa, Y.; Katoono, R.; Shimoyama, A.; Manabe, Y.; Fukase, K.; Fukushima, T.
    Narrower HOMO-LUMO gap attained by conformational switching through peripheral polyarylation in 1,4,5,8-tetraaza-9,10-anthraquinodimethanes.
    Tetrahedron 2018, 74, 2239-2244. DOI: 10.1016/j.tet.2018.03.041
  50. Manabe, Y.; Kasahara, S.; Takakura, Y.; Yang, X.; Takamatsu, S.; Kamada Y.; Miyoshi, M.; Yoshidome, D.; Fukasea, K.*
    Development of α1,6-fucosyltransferase inhibitors through the diversity-oriented syntheses of GDP-fucose mimics using the coupling between alkyne and sulfonyl azide.
    Bioorg. Med. Chem. 2017, 25, 2844-2850. DOI: 10.1016/j.bmc.2017.02.036
  51. Furuta, A.; Hirobe, H.; *Fukuyama, T.; Ryu, I.*; Manabe, Y.; Fukase, K.
    Flow Dehydration and Hydrogenation of Allylic Alcohols: Application to the Waste-Free Synthesis of Pristane.
    Eur. J. Org. Chem. 2017, 2017, 1365-1368. DOI: 10.1002/ejoc.201700072
  52. Nagasaki, M.; Manabe, Y.; Minamoto, N.; Tanaka, K.; Silipo, A.; Molinaro, A.; Fukase, K.*
    Chemical Synthesis of a Complex-Type N-Glycan Containing a Core Fucose.
    J. Org. Chem. 2016, 81, 10600-10616. DOI: 10.1021/acs.joc.6b02106
  53. Chen, S.; Manabe, Y.; Minamoto, Y.; Saiki, N.; Fukase, K.*
    Development of a simple assay system for protein-stabilizing efficiency based on hemoglobin protection against denaturation and measurement of the cooperative effect of mixing protein stabilizers.
    Bioscience, Biotechnology, and Biochemistry 2016, 80, 1874-1878. DOI:10.1080/09168451.2016.1189317
  54. Zhou, J.; Manabe, Y.; Tanaka, K.; Fukase, K.*
    Efficient synthesis of the disialylated tetrasaccharide motif in N-glycan via an amide protection strategy.
    Chem. Asian. J. 2016, 11, 1436-1440. DOI:10.100 2/asia.201 600139
  55. Ueda, M.*; Yang, G.; Nukadzuka, Y.; Ishimaru, Y.; Tamura, S.; Manabe, Y.
    Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity.
    Org. Biomol. Chem. 2015, 13, 55-58. DOI: 10.1039/C4OB02106A
  56. Manabe, Y.; Kitawaki, Y.; Nagasaki, M.; Fukase, K.* Matsubara, H.: Hino Y.; Fukuyama, T.; *Ryu, I.
    Revisiting Bromination of C-H Bonds with Molecular Bromine Using a Photo-Microflow System.
    Chem. Eur. J. 2014, 20, 12750-12753. DOI: 10.1002/chem.201402303
  57. Salmasan, R. M.; Manabe, Y.; Kitawaki, Y.; Chang, T.-C.; Fukase, K.* Efficient Glycosylation Using In(OTf)3 as a Lewis Acid: Activation of N-Phenyltrifluoroacetimidate or Thioglycosides with Halogenated Reagents or PhIO. Chem. Lett. 2014, 43, 956-958.　DOI: 10.1246/cl.140167
  58. Uchinashi, Y.; Tanaka, K.; Manabe, Y.; Fujimoto, Y.; Fukase, K.*
    Practical and Efficient Method for α-Sialylation with an Azide Sialyl Donor Using a Microreactor.
    J. Carbohydrate Chem., 2014, 33, 55-67. DOI: 10.1080/07328303.2014.880116
  59. Tanaka, K.; Matsumoto, R.; Pradipta, A. R.; Kitagawa, Y.; Okumura, M.; Manabe, Y.; Fukase, K.*
    Facile Preparation of 1,5-Diazacyclooctanes from Unsaturated Imines: Effects of the Hydroxyl Groups on [4+4] Dimerization.
    Synlett, 2014, 25, 1026-1030. DOI: 10.1055/s-0033-1340859
  60. Ebine, M.; Kanemoto, M.; Manabe, Y.; Konno, Y.; Sakai, K.; Matsumori, N.; Murata, M.; Oish, T.*
    Synthesis and Structure Revision of the C43–C67 Part of Amphidinol 3.
    Org. Lett. 2013, 15, 2846-2849. DOI: 10.1021/ol401176a
  61. Manabe, Y.; Ebine, M.; Matsumori, N.; Murata, M.; Oishi, T.*
    Confirmation of the Absolute Configuration at C45 of Amphidinol 3.
    J. Nat. Prod. 2012, 75, 2003-2006. DOI: 10.1021/np300604w
  62. Ueda, M.*; Manabe, Y.; Otsuka, Y.; Kanzawa, N.
    Cassia obtusifolia MetE as a Cytosolic Target for Potassium Isolespedezate, a Leaf-Opening Factor of Cassia plants: Target Exploration by a Compact Molecular-Probe Strategy.
    Chem. Asian. J. 2011, 6, 3286 -3297. DOI: 10.1002/asia.201100392
  63. Ueda, M.*; Manabe, Y.; Mukai, M.
    The High-performance of 3×FLAG for Target Purification of Bioactive Metaboliter: a Tag Combined with Highly Effective Linker Structure.
    Bioorg. Med. Chem. Lett. 2011, 21, 1359-1362.　DOI: 10.1016/j.bmcl.2011.01.038
  64. Nakamura, Y.; Inomata, S.; Ebine, M.; Manabe, Y.; Iwakura, I.; Ueda, M.*
    “Click-made” biaryl-linker improving efficiency in protein labeling for the membrane target protein of a bioactive compound.
    Org. Biomol. Chem. 2011, 9, 83-85. DOI:10.1039/c0ob00843e
  65. Manabe, Y.; Mukai, M.; Ito, S.; Kato, N.; Ueda, M.*
    FLAG Tagging by CuAAC and Nano-gram Scale Purification of the Target Protein for Bioactive Metabolite Concerning Circadian Rhythmic Leaf Movement of Leguminous.,
    Chem. Commun. 2010, 46, 469-471. DOI: 10.1039/B915843J
  66. Manabe, Y.; Iwakura, I.; Mukai, M.; Ueda, M.*
    A Target Protein for Potassium Isolespedezate, A Bioactive Metabolite Controlling Nyctinasty, IBC 2009, １, 1-5. DOI: 10.4051/ibc.2009.4.0014
  67. Fujii, T.; Kato, N.; Iwakura, I.; Manabe, Y.; Ueda, M.*
    Synthesis of Staudinger-type Molecular probe for Catch-and–release Purification of the Binding Protein for Potassium Isolespedezate, a leaf-closing Substance of Leguminous Plant.
    Chem. Lett. 2008, 37, 52-53. DOI: 10.1246/cl.2008.52
  68. Manabe, Y.; Sugimoto, T.; Kawasaki, T.; Ueda, M.*
    Nanometer-scale Direct Observation of the Receptor for Leaf-movement Factor in the Plant Cell by Using Novel TEM Probe,
    Tetrahedron Lett. 2007, 48, 1341-1344. DOI: 10.1016/j.tetlet.2006.12.128
  69. Fujii, T.; Manabe, Y.; Sugimoto, T.; Ueda, M.*
    Detection of 210 kDa and 180 kDa Receptor Proteins for a Leaf-Movement Factor by Using Novel Photoaffinity Probes,
    Tetrahedron 2005, 61, 7874-7893. DOI: 10.1016/j.tetlet.2006.12.128

Reviews

  1. Manabe, Y.*; Fukase, K.*
    Novel immune therapy: antibody-recruiting strategy.
    Chem. Lett. 2025, 54, upaf035. DOI: 10.1093/chemle/upaf035.
  2. Kametani, Y.*; Ito, R.; Manabe, Y.; Kulski, J. K.; Seki, T.; Ishimoto, H.; Shiina, T.
    PBMC-engrafted humanized mice models for evaluating immune-related and anticancer drug delivery systems.
    Front. Mol. Biosci. 2024, 20, 1447315, DOI: 10.3389/fmolb.2024.1447315.
  3. Fukase, K.*; Manabe, Y.; Shimoyama, A.
    Diacetyl strategy for synthesis of NHAc containing glycans: enhancing glycosylation reactivity via diacetyl imide protection.
    Front. Chem. 2023, 11, 1319883. DOI: 10.3389/fchem.2023.1319883.
  4. Manabe, Y.*
    Chemical Biology Study for Elucidating and Regulating Emergent Glycan Functions,
    Journal of Synthetic Organic Chemistry, Japan 2023, 81(2), 96-104. DOI: 10.5059/yukigoseikyokaishi.81.96
  5. Manabe, Y.*
    Chemical biology study on N-glycans.
    Trends in Glycosci. Glycotechnol. 2021, 33(193), E63-E67. DOI: 10.4052/tigg.2109.2E
  6. Shirakawa, A.; Manabe, Y.*; Fukase, K.*
    Recent Advances in the Chemical Biology of N-Glycans.
    Molecules, 2021, 26(4), 1040. DOI: 10.1002/anie.202111035
  7. Manabe, Y.*; Chang, T.-C.; Fukase, K.*
    Recent advances in self-adjuvanting glycoconjugate vaccines.
    Drug Discov. Today Technol. 2020. DOI: 10.1016/j.ddtec.2020.11.006
  8. Manabe, Y.; Shimoyama, A.; Kabayama, K.; Fukase, K.*
    Middle molecular and conjugation strategies for development of bioactive middle molecules.
    Journal of Synthetic Organic Chemistry, Japan 2020, 78(5), 527-537. DOI: 10.5059/yukigoseikyokaishi.78.527
  9. Manabe, Y.*
    Synthetic Study of N-glycans
    Journal of Synthetic Organic Chemistry, Japan 2018, 76, 502-505. DOI:10.5059/yukigoseikyokaishi.76.502
  10. Fukase, K.*; Shimoyama, A.; Manabe, Y.
    Effective Synthesis of Oligosaccharide under Microfluidic Conditions.
    Journal of synthetic Organic Chemistry, Japan 2015, 73, 452-459. DOI: 10.5059/yukigoseikyokaishi.73.452
  11. Manabe, Y.*
    Recent Advance in Copper-Free Click Chemistry Using Cyclooctynes, and Applications for Living Systems.
    Journal of synthetic Organic Chemistry, Japan 2012, 70, 754-755.　DOI: 10.5059/yukigoseikyokaishi.70.754
  12. Nakamura, Y.; Manabe, Y.; Inomata S.; Ueda, M.*
    Recent Advances on Bioorganic chemistry of Plant Metabolites Controlling Nyctinasty,
    The Chemical Record 2010, 10, 70-79.　DOI: 10.1002/tcr.200900021
  13. Manabe, Y.; Inomata, S.; Ueda, M.*
    Chemical Biology of Glycoside-type Bioactive Substance Controlling Nyctinastic Movement in Leguminous Plants,
    Trends in Glycoscience and Glycotechnology 2010, 22, 16-25. DOI: 10.4052/tigg.22.16
  14. Shoji, M.; Kato, E.; Nakamura, Y.; Fujii, T. Manabe, Y.; Ueda, M. *
    Bioorganic Studies on Plant Movement, from Natural Products to Its Receptor,
    The Chemical Record 2006, 6, 344-355.　DOI: 10.1002/tcr.20102
トップへ戻るボタン