The method of manipulating the genome, which is whole genetic information, is called "genome-editing technology". In recent years, genome-editing technology is used in various life-science research fields. Our laboratory has started in August 2017, and develops innovative genomic-editing technologies. Recently, we have developed a robust Homology-Independent Targeted Integration (HITI) technology that allows for efficient targeted knock-in in both dividing and non-dividing cells in vitro and in vivo (Suzuki et al, Nature 2016). Moreover, and as a first proof of concept, by using a rat model of blindness retinitis pigmentosa (RP), we demonstrated the therapeutic efficacy and functional rescue of RP in vivo. Our laboratory aims to develop genetic tools which are useful for future clinical applications such as genome-editing therapy of genetic diseases.
- November 13, 2017
- A review paper has been published in Journal of Human Genetics.
- August 01, 2017
- Keiichiro Suzuki laboratory has started at Osaka University.