大阪大学 高等共創研究院 大阪大学 基礎工学研究科 物質創成専攻 機能物質化学領域　鈴木 (啓) 研究室

発表論文

主要な論文

• Shiraishi M, Nabeshima N, Suzuki, K., Fujita M, Iwai S. Endonuclease Q as a robust enhancer for nucleic acid amplification. Anal Biochem 692, 115569 (2024)
• Furuno, K., Suzuki, K.# and Sakai S#. Transduction and Genome Editing of the Heart with Adeno-Associated Viral Vectors Loaded onto Electrospun Polydioxanone Nonwoven Fabrics. Biomoleucules 14, 506(2024)
  #Corresponding auther
• Liu, M., Zhang, C., Gong, X., Zhang, T., Lian, M.M., Chew, E.G.Y., Cardilla, A., Suzuki, K., Wang, H., Yuan, Y., Li, Y., Naik, M.Y., Wang, Y., Zhou, B., Soon, W.Z., Aizawa, E., Li, P., Low, J.H., Tandiono, M., Montagud, E., Moya-Rull, D., Rodriguez Esteban, C., Luque, Y., Fang, M., Khor, C.C., Montserrat, N., Campisto,l J.M., Izpisua Belmonte, J.C., Foo, J.N. and Xia, Y. Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo. Cell Stem Cell 31, 52-70 (2024)
• Furuno, K., Elvitigala, K.C.M.L., Suzuki, K.# and Sakai S#. Local delivery of adeno-associated viral vectors with electrospun gelatin nanofiber mats. J Biomed Mater Res B Appl Biomater 112, e35345 (2024)
  #Corresponding auther
• Kodera, T., Takeuchi, R.F., Takahashi, S., Suzuki, K., Kassai, H., Aiba, A., Shiozawa, S., Okano, H. and Osakada, F. Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids. BBRC 657, 119-127 (2023)
• Akaba, Y., Takahashi, S.,Suzuki, K., Kosaki, K. and Tsujimura, K. miR-514a promotes neuronal development in human iPSC-derived neurons. Front Cell Dev Biol 11, 1096463 (2023)
• Furuno, K., Suzuki, K.#,and Sakai, S#. Gelatin-Based Electrospun Nanofibers Cross-Linked Using Horseradish Peroxidase for Plasmid DNA Delivery. Biomoleucules 12, 1638 (2022)
  #Corresponding author
• Furuno, K., Suzuki, K., and Sakai, S. Gelatin nanofiber mats with Lipofectamine/plasmid DNA complexes for genome editing. J Colloids Surf B Biointerfaces 216, 112561 (2022)
• Yuan, B., Zhou, X, Suzuki, K., Ramos-Mandujano, G., Wang, M., Tehseen, M., Cortés-Medina, L.V., Moresco, J.J., Dunn, S., Hernandez-Benitez, R., Hishida, T., Kim, N.Y., Andijani, M.M., Bi, C., Ku, M, Takahashi Y, Xu J, Qiu J, Huang L, Benner C, Aizawa, E., Qu J, Liu GH, Li Z, Yi F, Ghosheh Y, Shao C., Shokhirev, M., Comoli, P., Frassoni, F., Yates, JR 3rd,. Fu, X.D., Esteban, C.R., Hamdan, S., Li, M. and Izpisua Belmonte, J.C. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing. Nat Commun 13, Article number: 3646 (2022)
• Kuwayama, R.,Suzuki, K., Nakamura, J., Aizawa, E., Yoshioka, Y., Ikawa, M., Nabatame, S., Inoue, K.I., Shimmyo, Y., Ozono, K., Kinoshita, T. and Murakami, Y. Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy. Nat commun 13, Article number: 3107 (2022)
• Giorgetti, A#., Gu, Y#., Suzuki, K.# and Li, M#. Editorial: Developmental models 2.0. Front Cell Dev Biol 10, 1055139 (2022)
  #Corresponding author
• Furuno, K., Wang, J., Suzuki, K., Nakahata, M. and Sakai, S. Gelatin-Based Electrospun Fibers Insolubilized by Horseradish Peroxidase-Catalyzed Cross-Linking for Biomedical Applications. ACS Omega 5, 21254-21259 (2020)
• Wang, S., Min, Z., Ji, Q., Geng, L., Su, Y., Liu, Z., Hu, H., Wang, L., Zhang, W., Suzuki, K., Huang, Y., Zhang, P,, Tang, T.S., Qu, J., Yu, Y., Liu, G.H. and Qiao, J. Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction. Protein Cell 11, 1-22 (2020)
• Suzuki, K.#, Yamamoto, M., Hernandez-Benitez, R., Li, Z., Wei, C., Soligalla, R.D., Aizawa, E., Hatanaka, F., Kurita, M., Reddy, P., Ocampo, A., Hishida, T., Sakurai, M., Nemeth, A.N., Nuñez Delicado , E., Campistol, J.M., Magistretti, P., Guillen, P., Esteban, C.R., Gong, J., Yuan, Y., Gu, Y, Liu, G.H., López-Otín, C., Wu, J., Zhang, K. and Izpisua Belmonte, J.C#. Precise In vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction. Cell Res 29, 804-819 (2019)
  #Corresponding author
  Selected as 2019 Sanofi-Cell Research Outstanding Paper Award
• Yan, P., Li, Q., Wang, L., Lu, P., Suzuki, K., Liu, Z., Lei, J., Li, W., He, X., Wang, S., Ding, J., Chan, P., Zhang, W., Song, M., Izpisua Belmonte, J.C., Qu, J., Tang, F. and Liu, G.H. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell stem cell 24, 447-461 (2019)
• Low, H.W., Li, P., Chew, E.G.Y., Zhou, B., Suzuki, K., Zhang, T., Lian, M.M., Liu, M., Aizawa, E., Esteban, C.R. Yong, K.S.M., Chen, Q., Campistol, J.M., Fang, M., Khor, C.C., Foo, J.N., Izpisua Belmonte, J.C. and Xia, Y. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network. Cell stem cell 25, 373-387 (2019)
• Wu, Z., Zhang, W., Song, M., Wang, W., Wei, G., Li, W., Lei, J., Huang, Y., Sang, Y., Chan, P., Chen, C., Qu, J., Suzuki, K.#, Izpisua Belmonte, J.C#. and Liu, G.H#. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein Cell 4, 333-350 (2018)
• Kurita, M., Araoka, T., Hishida, T., O'Keefe, D.D., Takahashi, Y., Sakamoto A., Sakurai, M., Suzuki, K., Wu, J., Yamamoto, M., Hernandez-Benitez, R., Ocampo, A., Reddy, P., Shokhirev, M.N., Magistretti, P., Núñez Delicado, E., Eto, H., Harii, K., Izpisua Belmonte, J.C. In vivo reprogramming of wound-resident cells generates skin epithelial tissue. Nature 561, 243-247 (2018)
• Bogliotti. Y.S., Jun Wu, Vilarino, M., Okamura, D., Soto, D.A., Zhong, C., Sakurai, M., Sampaio, R.V., Suzuki, K., Izpisua Belmonte, J.C. and Ross, P. SJ. Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts. Proc Natl Acad Sci USA 115,2090-2095 (2018)
• Suzuki, K.# and Izpisua Belmonte, J.C.　In vivo genome editing via the HITI method as a tool for gene therapy. J Hum Genet 63, 157–164 (2018) doi:10.1038/s10038-017-0352-4
  #Corresponding author
• Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Lee, Y., Suzuki, K., Koski A., Ji, D., Hayama, T., Ahmed, R., Darby, H , Dyken, C. V., Li, Y., Kang, E., Park, A. R., Kim, D., Kim, S.T., Gong, J., Gu, Y., Xu, X, Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Heitner, S. B., Izpisua Belmonte, J. C., Amato, P., Kim, J. S., Kaul, S. and Mitalipov, S. Correction of a Pathogenic Gene Mutation in Human Embryos. Nature 548, 413-419 (2017) doi:10.1038/nature23305
• Takahashi, Y., Wu, J, Suzuki, K., Martinez-Redondo, P., Li, M., Liao, H.K., Wu, M.Z., Hernández-Benítez, R. Hishida, T. Nikolaievich Shokhirev, M., Rodriguez Esteban, C., Sancho-Martinez, I. and Izpisua Belmonte, J.C. Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. Science 356, 503-508 (2017) doi: 10.1126/science.aag3260
• Wu, J., Platero Luengo, A., Sakurai, M., Sugawara, A., Gil, M.A., Yamauchi, T., Suzuki, K., Soledad Bogliotti, Y., Cuello, C., Morales Valencia, M., Okumura, D., Luo, j., Vilarino, M., Parrilla, I., Soto, D., Martinez, C.A., Hishida, T., Martinez, L., Sanchez, S., Wang, H., Nohalez, A., Aizawa, E., Martinez-Redondo, P., Ocampo, A., Reddy, P., Roca, J., Maga, E.A., Rodriguez Esteban, C, Berggren, W.T., Nuñez, E., Lajara, J., Guillen, I., Guillen, P., Campistol, J.M., Martinez, E.A., Ross, P. J. and Izpisua Belmonte, J.C. Interspecies chimerism with mammalian pluripotent stem cells. Cell 168, 473-486 (2017) doi: 10.1016/j.cell.2016.12.036
• Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J, Kim, J. E., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., Kurita, M., Hishida, T., Li, M., Aizawa, E., Guo, S., Chen, S., Goebl, A., Soligalla, R.D., Qu, J., Jiang, T., Fu, X., Jafari, M., Esteban, C.R., Berggren, T., Lajara, J., Nuñez, E., Guillen, P., Campistol, J.M., Matsuzaki, F., Liu, G.H., Magistretti, P., Zhang, K., Callaway, E.M., Zhang, K. and Izpisua Belmonte, J.C. In vivo genome editing via CRISPR-Cas9 mediated homology-independent targeted integration. Nature 540, 144-149 (2016) doi:10.1038/nature20565
• Zhang, W.*, Li, J.*, Suzuki, K.*, Qu, J.*, Wang, P., Zhou, J., Liu, X., Ren. R., Xu., X., Ocampo, A., Yuan, T., Yang, J., Li, Y., Shi, L., Guan, D., Pan, H., Duan, S., Ding, Z., Li, M., Yi, F., Bai, R., Wang, Y., Chen, C., Yang, F., Li, X., Wang, Z., Aizawa, E., Goebl, A., Soligalla, R.D., Reddy, P., Esteban, C.R., Tang, F., Liu, G.H. and Izpisua Belmonte, J.C. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science 343, 1160-1163 (2015) doi: 10.1126/science.aaa1356
  *These authors contributed equally to this work
• Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M.N., Nery, J.R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N.Y., Lajara, J., Guillen, R., Campistol, J.M., Esteban, C.R., Ross, P.J., Saghatelian, A., Ren, B., Ecker, J.R. and Izpisua Belmonte, J.C. An alternative pluripotent state confers interspecies chimaera competency. Nature 521, 316-321 (2015) doi: 10.1038/nature14413
• Reddy, P., Ocampo, A., Suzuki, K., Luo, J., Bacman, S.R, Williams, S.L., Sugawara, A., Okamura, D., Tsunekawa, Y., Lam, D., Xiong, X., Monsterrat, N., Esteban, C.R., Liu, G.H., Sancho-Martinez, I., Manau, D., Civico, S., Cardellach, F., O’Callaghan, M.D.M., Campistol, J., Zhao, H., Campistol, J.M., Moraes, C.T. and Izpisua Belmonte, J.C. Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing. Cell 161, 459-469 (2015) doi: 10.1016/j.cell.2015.03.051
• Suzuki, K., Yu, C., Qu, J. , Li, M., Yao, X, Yuan, t., Goebl, A., Tang, S., Ren, R., Aizawa, E., Zhang, F., Xu, X., Soligalla, R.D., Chen, F., Kim, J., Kim, N.Y., Liao, H.K., Benner, C., Esteban, C.R., Jin, Y., Liu, G.H., Li, Y. and Izpisua Belmonte, J.C. Targeted gene correction in human disease-specific induced pluripotent stem cells minimally impacts whole-genome mutational load. Cell Stem Cell 15, 31-36 (2014) doi: 10.1016/j.stem.2014.06.016
• Liu, G.H.*, Suzuki, K.*, Li, M.*, Qu, J.*, Monserrat, N., Tarantino, C., Gu, Y., Yi, F., Xu, X., Zhang, W., Ruiz, S., Plongthongkum, N., Zhang, Kun., Masuda, S., Nivet, E., Tsunekawa, Y., Soligalla, R.D., Goebl, A., Aizawa, E., Kim, N.Y., Kim, J., Dubova, I., Li, Ying., Ren, R., Benner, C., del Sol, A., Bueren, j., Trujillo , J.P., Surralles, J., Cappelli, E., Dufour, C., Esteban, C.R. and Izpisua Belmonte, J.C. Modeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. Nature Communications 5, Article number: 4330 (2014) doi: 10.1038/ncomms5330
  *These authors contributed equally to this work
• Liu, G.H.*, Qu, J.*, Suzuki, K.*, Nivet, E., Li, M. Monserrat, N., Yi, F., Xu, X., Ruiz, S., Zhang, W., Ren, B., Wagner, U., Kim, A., Li, Y., Goebl, A., Kim, J., Soligalla, R.D., Dubova, I., Thompson, J., Yates III, J., Esteban, C.R., Sancho-Martinez, I. and Izpisua Belmonte, J.C. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature 491, 603–607 (2012) doi:10.1038/nature11557
  *These authors contributed equally to this work
• Liu, G.H.*, Suzuki, K.*, Qu, J.*, Sancho-Martinez, I., Yi, F., Li, M., Kumar, S., Nivet, E., Kim, J., Soligalla, R.D., Dubova, I., Goebl, A., Plongthongkum, N., Fung, H.L., Zhang, K., Loring, J.F., Laurent, L.C. and Izpisua Belmonte, J.C. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell 8, 688-694 (2011) doi: 10.1016/j.stem.2011.04.019
  *These authors contributed equally to this work
• Suzuki, K., Mitsui, K., Aizawa, E., Hasegawa, K., Kawase, E., Yamagishi, T., Shimizu, Y., Suemori, H., Nakatsuji, N. and Mitani, K. Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors. Proc Natl Acad Sci USA 105, 13781-13786 (2008) doi: 10.1073/pnas.0806976105
• Ishibashi, K.*, Suzuki, K.*, Ando, Y., Takakura, C. and Inoue, H. Nonhomologous chromosomal integration of foreign DNA is completely dependent on MUS-53 (human Lig4 homolog) in Neurospora. Proc Natl Acad Sci USA 103, 14871-14876 (2006) doi: 10.1073/pnas.0604477103
  *These authors contributed equally to this work