大阪大学 高等共創研究院 大阪大学 基礎工学研究科 物質創成専攻 機能物質化学領域　鈴木 (啓) 研究室

発表論文

主要な論文

  • Suzuki, K.# and Izpisua Belmonte, J.C.　In vivo genome editing via the HITI method as a tool for gene therapy. Journal of Human Genetics 63, 157–164 (2018) doi:10.1038/s10038-017-0352-4
    #Corresponding author
  • Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Lee, Y., Suzuki, K., Koski A., Ji, D., Hayama, T., Ahmed, R., Darby, H , Dyken, C. V., Li, Y., Kang, E., Park, A. R., Kim, D., Kim, S.T., Gong, J., Gu, Y., Xu, X, Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Heitner, S. B., Izpisua Belmonte, J. C., Amato, P., Kim, J. S., Kaul, S. and Mitalipov, S. Correction of a Pathogenic Gene Mutation in Human Embryos. Nature 548, 413-419 (2017) doi:10.1038/nature23305
  • Takahashi, Y., Wu, J, Suzuki, K., Martinez-Redondo, P., Li, M., Liao, H.K., Wu, M.Z., Hernández-Benítez, R. Hishida, T. Nikolaievich Shokhirev, M., Rodriguez Esteban, C., Sancho-Martinez, I. and Izpisua Belmonte, J.C. Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. Science 356, 503-508 (2017) doi: 10.1126/science.aag3260
  • Wu, J., Platero Luengo, A., Sakurai, M., Sugawara, A., Gil, M.A., Yamauchi, T., Suzuki, K., Soledad Bogliotti, Y., Cuello, C., Morales Valencia, M., Okumura, D., Luo, j., Vilarino, M., Parrilla, I., Soto, D., Martinez, C.A., Hishida, T., Martinez, L., Sanchez, S., Wang, H., Nohalez, A., Aizawa, E., Martinez-Redondo, P., Ocampo, A., Reddy, P., Roca, J., Maga, E.A., Rodriguez Esteban, C, Berggren, W.T., Nuñez, E., Lajara, J., Guillen, I., Guillen, P., Campistol, J.M., Martinez, E.A., Ross, P. J. and Izpisua Belmonte, J.C. Interspecies chimerism with mammalian pluripotent stem cells. Cell 168, 473-486 (2017) doi: 10.1016/j.cell.2016.12.036
  • Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J, Kim, J. E., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., Kurita, M., Hishida, T., Li, M., Aizawa, E., Guo, S., Chen, S., Goebl, A., Soligalla, R.D., Qu, J., Jiang, T., Fu, X., Jafari, M., Esteban, C.R., Berggren, T., Lajara, J., Nuñez, E., Guillen, P., Campistol, J.M., Matsuzaki, F., Liu, G.H., Magistretti, P., Zhang, K., Callaway, E.M., Zhang, K. and Izpisua Belmonte, J.C. In vivo genome editing via CRISPR-Cas9 mediated homology-independent targeted integration. Nature 540, 144-149 (2016) doi:10.1038/nature20565
  • Zhang, W.*, Li, J.*, Suzuki, K.*, Qu, J.*, Wang, P., Zhou, J., Liu, X., Ren. R., Xu., X., Ocampo, A., Yuan, T., Yang, J., Li, Y., Shi, L., Guan, D., Pan, H., Duan, S., Ding, Z., Li, M., Yi, F., Bai, R., Wang, Y., Chen, C., Yang, F., Li, X., Wang, Z., Aizawa, E., Goebl, A., Soligalla, R.D., Reddy, P., Esteban, C.R., Tang, F., Liu, G.H. and Izpisua Belmonte, J.C. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science 343, 1160-1163 (2015) doi: 10.1126/science.aaa1356
    *These authors contributed equally to this work
  • Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M.N., Nery, J.R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N.Y., Lajara, J., Guillen, R., Campistol, J.M., Esteban, C.R., Ross, P.J., Saghatelian, A., Ren, B., Ecker, J.R. and Izpisua Belmonte, J.C. An alternative pluripotent state confers interspecies chimaera competency. Nature 521, 316-321 (2015) doi: 10.1038/nature14413
  • Reddy, P., Ocampo, A., Suzuki, K., Luo, J., Bacman, S.R, Williams, S.L., Sugawara, A., Okamura, D., Tsunekawa, Y., Lam, D., Xiong, X., Monsterrat, N., Esteban, C.R., Liu, G.H., Sancho-Martinez, I., Manau, D., Civico, S., Cardellach, F., O’Callaghan, M.D.M., Campistol, J., Zhao, H., Campistol, J.M., Moraes, C.T. and Izpisua Belmonte, J.C. Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing. Cell 161, 459-469 (2015) doi: 10.1016/j.cell.2015.03.051
  • Suzuki, K., Yu, C., Qu, J. , Li, M., Yao, X, Yuan, t., Goebl, A., Tang, S., Ren, R., Aizawa, E., Zhang, F., Xu, X., Soligalla, R.D., Chen, F., Kim, J., Kim, N.Y., Liao, H.K., Benner, C., Esteban, C.R., Jin, Y., Liu, G.H., Li, Y. and Izpisua Belmonte, J.C. Targeted gene correction in human disease-specific induced pluripotent stem cells minimally impacts whole-genome mutational load. Cell Stem Cell 15, 31-36 (2014) doi: 10.1016/j.stem.2014.06.016
  • Liu, G.H.*, Suzuki, K.*, Li, M.*, Qu, J.*, Monserrat, N., Tarantino, C., Gu, Y., Yi, F., Xu, X., Zhang, W., Ruiz, S., Plongthongkum, N., Zhang, Kun., Masuda, S., Nivet, E., Tsunekawa, Y., Soligalla, R.D., Goebl, A., Aizawa, E., Kim, N.Y., Kim, J., Dubova, I., Li, Ying., Ren, R., Benner, C., del Sol, A., Bueren, j., Trujillo , J.P., Surralles, J., Cappelli, E., Dufour, C., Esteban, C.R. and Izpisua Belmonte, J.C. Modeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. Nature Communications 5, Article number: 4330 (2014) doi: 10.1038/ncomms5330
    *These authors contributed equally to this work
  • Liu, G.H.*, Qu, J.*, Suzuki, K.*, Nivet, E., Li, M. Monserrat, N., Yi, F., Xu, X., Ruiz, S., Zhang, W., Ren, B., Wagner, U., Kim, A., Li, Y., Goebl, A., Kim, J., Soligalla, R.D., Dubova, I., Thompson, J., Yates III, J., Esteban, C.R., Sancho-Martinez, I. and Izpisua Belmonte, J.C. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature 491, 603–607 (2012) doi:10.1038/nature11557
    *These authors contributed equally to this work
  • Liu, G.H.*, Suzuki, K.*, Qu, J.*, Sancho-Martinez, I., Yi, F., Li, M., Kumar, S., Nivet, E., Kim, J., Soligalla, R.D., Dubova, I., Goebl, A., Plongthongkum, N., Fung, H.L., Zhang, K., Loring, J.F., Laurent, L.C. and Izpisua Belmonte, J.C. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell 8, 688-694 (2011) doi: 10.1016/j.stem.2011.04.019
    *These authors contributed equally to this work
  • Suzuki, K., Mitsui, K., Aizawa, E., Hasegawa, K., Kawase, E., Yamagishi, T., Shimizu, Y., Suemori, H., Nakatsuji, N. and Mitani, K. Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors. Proc Natl Acad Sci USA 105, 13781-13786 (2008) doi: 10.1073/pnas.0806976105
  • Ishibashi, K.*, Suzuki, K.*, Ando, Y., Takakura, C. and Inoue, H. Nonhomologous chromosomal integration of foreign DNA is completely dependent on MUS-53 (human Lig4 homolog) in Neurospora. Proc Natl Acad Sci USA 103, 14871-14876 (2006) doi: 10.1073/pnas.0604477103
    *These authors contributed equally to this work